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Percocet is a prescription pain medication that combines oxycodone, an opioid analgesic, with acetaminophen. Historically, Percocet formulations have been available with different amounts of acetaminophen. Therefore, the exact strength shown on the prescription or original packaging should always be confirmed before use. FDA labeling documents a 7.5mg oxycodone/325mg acetaminophen formulation, while older formulations used different acetaminophen strengths.
Because oxycodone can cause dependence, misuse, overdose, and potentially life-threatening breathing problems, Percocet should only be used under appropriate medical supervision.
Oxycodone works by changing how the brain and nervous system respond to pain. Acetaminophen provides additional pain-relieving effects. Together, these ingredients may be prescribed for pain that requires an opioid medication.
However, the acetaminophen component requires particular attention. Taking additional medicines that contain acetaminophen can unintentionally increase the total daily amount and raise the risk of liver injury. Patients should check all prescription and nonprescription medicines with a healthcare professional or pharmacist.
Oxycodone may cause drowsiness, dizziness, nausea, constipation, and other adverse effects. More importantly, it can slow breathing, particularly when treatment begins or when the dose increases. Extreme sleepiness, unusually slow breathing, long pauses between breaths, or difficulty waking require emergency medical attention.
Furthermore, alcohol and certain medicines can increase sedation and respiratory-depression risks. This includes some other central nervous system depressants. For that reason, patients should provide their doctor and pharmacist with a complete list of medicines, supplements, and substances they use.
Acetaminophen can also cause serious liver damage when too much is taken. Consequently, patients should avoid accidentally combining multiple acetaminophen-containing products and should follow the prescribed directions carefully.
Percocet should be taken exactly as prescribed. Do not increase the amount, take it more frequently, or share it with another person. Oxycodone-containing medicines can be habit-forming, even when taken according to a prescription.
In addition, medication should be stored securely and kept away from children and other people who could accidentally or intentionally take it. Unused opioid medication should be disposed of according to local medication take-back or disposal guidance.
Anyone considering or currently using Percocet should discuss its benefits, risks, interactions, and appropriate duration with a qualified healthcare professional. The exact product strength should also be verified because oxycodone/acetaminophen formulations have changed over time.



